What Are Cannabinoids?
Chemical Compounds Essential to Health
How Cannabinoids Works
Cannabinoids are chemical compounds organically produced by the hemp plant and provide numerous health benefits by interacting with a person’s ECS (Endocannabinoid System). The ECS is a network of cell receptors throughout the human body which directly interact with cannabinoids. The ECS is a key player in an assortment of physiological human processes, some examples include pain, appetite, inflammation, mood, memory and the immune system.
The Endocannabinoid System (ECS)
- Universal in humans
- Exists in most invertebrates and all vertebrates
- Receptors occur in the brain, digestive and lymphatic systems
- Key player in Homeostasis: breath regulation, inflammatory issues, immune responses, pain, moods, Gastrointestinal motility, neuroprotection, balancing hormones, sleep and awake cycles, blood pressure, tumor observation and reproduction
- Only instructed in 13% of programs in pharmacy, nursing and medical fields
- Responsible for “runner’s high”, may activate when jogging or running
- May stimulate during acupuncture procedures and osteopathic manipulative treatments
- Comprised of both CB1 & CB2 receptors
Mechanisms of Action
Cannabidiol, most commonly known as CBD, binds to TRPV-1, a G-coupled protein. TRPV-1 plays a large role in the perception of pain, body temperature and inflammation. Numerous studies by the NIH have revealed that’s FAAH activity is inhibited by CBD. FAAH activity is mainly responsible for the decline of N-arachidonoylethanolamine, generally known as anandamide. Additionally, CBD hinders the reuptake of anandamide. Scientists responsible for discovering and isolating anandamide, a neurotransmitter, identified it as a mood elevator. Typical anandamide levels have a short half-life and are very low. CBD is an important aspect in that it helps prevent the deterioration of anandamide as well as the increase of endogenous levels. Ananda Hemp’s additional cannabinoid compounds are invaluable on their own. These compounds are responsible in achieving CBD’s benefits which include anti-inflammatory, neuroprotective and mood enhancing potential by working in synergy, thereby producing an “entourage effect”, a phenomena coined by scientists.
Contrary to THC, cannabinoids and CBD are non-psychoactive. Early studies have shown, that even at very high doses, CBD continued to remain non-psychoactive. Investigative studies in immunocompromised patients pertaining to immunomodulation of cannabinoids has been studied. While CB1 agonists, such as THC has shown to be maladaptive with people with liver fibrosis, evidence maintains the safety of CBD. Ananda Hemp products all contain less than 0.3% of THC. People on SSRI’s are cautioned as there are currently no published research and reports for CBD induced serotonin syndrome. As recommended by the American College of Obstetrics and Gynecology, both pregnant and breastfeeding women should not use marijuana since animal studies have discovered possible threats of THC. CBD and CBN revealed no negative consequences in both animal studies and studies in vitro. Presently, ACOG does not have any recommendations on hemp products for women that are pregnant and/or breastfeeding. Evidence of recommendation or eliminating of hemp is not available.